top of page

Our Publications

  1. Buss, E., Stahl, A., Geertz, R. & Gercken, G. Cytotoxic effects of dust particles on alveolar macrophages. Journal of Aerosol Science 21, Supplement 1, S497-S500 (1990).

  2. Stahl, A. & Mueller, B. M. Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro. Cancer research 54, 3066-3071 (1994).

  3. Stahl, A. & Mueller, B. M. The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae. J Cell Biol 129, 335-344 (1995).

  4. Stahl, A. & Mueller, B. M. Melanoma cell migration on vitronectin: regulation by components of the plasminogen activation system. International journal of cancer 71, 116-122 (1997).

  5. Hirsch, D., Stahl, A. & Lodish, H. F. A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci U S A 95, 8625-8629 (1998). https://doi.org/10.1073/pnas.95.15.8625

  6. Stahl, A., Hirsch, D. J., Gimeno, R. E., Punreddy, S., Ge, P., Watson, N., Patel, S., Kotler, M., Raimondi, A., Tartaglia, L. A. & Lodish, H. F. Identification of the major intestinal fatty acid transport protein. Mol Cell 4, 299-308 (1999). https://doi.org/10.1016/s1097-2765(00)80332-9

  7. Stahl, A., Gimeno, R. E., Tartaglia, L. A. & Lodish, H. F. Fatty acid transport proteins: a current view of a growing family. Trends in endocrinology and metabolism: TEM 12, 266-273 (2001). https://doi.org/10.1016/s1043-2760(01)00427-1

  8. Stahl, A., Evans, J. G., Pattel, S., Hirsch, D. & Lodish, H. F. Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. Dev Cell 2, 477-488. (2002).

  9. Gimeno, R. E., Hirsch, D. J., Punreddy, S., Sun, Y., Ortegon, A. M., Wu, H., Daniels, T., Stricker-Krongrad, A., Lodish, H. F. & Stahl, A. Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem 278, 49512-49516 (2003). https://doi.org/10.1074/jbc.M309759200

  10. Gimeno, R. E., Ortegon, A. M., Patel, S., Punreddy, S., Ge, P., Sun, Y., Lodish, H. F. & Stahl, A. Characterization of a heart-specific fatty acid transport protein. J Biol Chem 278, 16039-16044. (2003).

  11. Kim, J. K., Gimeno, R. E., Higashimori, T., Kim, H. J., Choi, H., Punreddy, S., Mozell, R. L., Tan, G., Stricker-Krongrad, A., Hirsch, D. J., Fillmore, J. J., Liu, Z. X., Dong, J., Cline, G., Stahl, A., Lodish, H. F. & Shulman, G. I. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest 113, 756-763 (2004).

  12. Mashek, D. G., Bornfeldt, K. E., Coleman, R. A., Berger, J., Bernlohr, D. A., Black, P., DiRusso, C. C., Farber, S. A., Guo, W., Hashimoto, N., Khodiyar, V., Kuypers, F. A., Maltais, L. J., Nebert, D. W., Renieri, A., Schaffer, J. E., Stahl, A., Watkins, P. A., Vasiliou, V. & Yamamoto, T. T. Revised nomenclature for the long chain mammalian acyl-CoA synthetase gene family. J Lipid Res (2004).

  13. Stahl, A. A current review of fatty acid transport proteins (SLC27). Pflugers Arch 447, 722-727 (2004). https://doi.org/10.1007/s00424-003-1106-z

  14. Stiles, B., Wang, Y., Stahl, A., Bassilian, S., Lee, W. P., Kim, Y. J., Sherwin, R., Devaskar, S., Lesche, R., Magnuson, M. A. & Wu, H. Live-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity. Proc Natl Acad Sci U S A 101, 2082-2087 (2004).

  15. Yu, K. C., David, C., Kadambi, S., Stahl, A., Hirata, K., Ishida, T., Quertermous, T., Cooper, A. D. & Choi, S. Y. Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice. J Lipid Res 45, 1614-1623 (2004).

  16. Johnson, A. C., Stahl, A. & Zager, R. A. Triglyceride accumulation in injured renal tubular cells: alterations in both synthetic and catabolic pathways. Kidney Int 67, 2196-2209 (2005).

  17. Liao, J., Sportsman, R., Harris, J. & Stahl, A. Real-time quantification of fatty acid uptake using a novel fluorescence assay. J Lipid Res 46, 597-602 (2005).

  18. Schmuth, M., Ortegon, A. M., Mao-Qiang, M., Elias, P. M., Feingold, K. R. & Stahl, A. Differential expression of fatty acid transport proteins in epidermis and skin appendages. J Invest Dermatol 125, 1174-1181 (2005). https://doi.org/10.1111/j.0022-202X.2005.23934.x

  19. Stahl, A. A case of mistaken identity. Am J Physiol Heart Circ Physiol 288, H448; author reply H448-450 (2005).

  20. Doege, H., Baillie, R. A., Ortegon, A. M., Tsang, B., Wu, Q., Punreddy, S., Hirsch, D., Watson, N., Gimeno, R. E. & Stahl, A. Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis. Gastroenterology 130, 1245-1258 (2006). https://doi.org/10.1053/j.gastro.2006.02.006

  21. Doege, H. & Stahl, A. Protein-mediated fatty acid uptake: novel insights from in vivo models. Physiology (Bethesda) 21, 259-268 (2006).

  22. Hubbard, B., Doege, H., Punreddy, S., Wu, H., Huang, X., Kaushik, V. K., Mozell, R. L., Byrnes, J. J., Stricker-Krongrad, A., Chou, C. J., Tartaglia, L. A., Lodish, H. F., Stahl, A. & Gimeno, R. E. Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology 130, 1259-1269 (2006). https://doi.org/10.1053/j.gastro.2006.02.012

  23. Wu, Q., Kazantzis, M., Doege, H., Ortegon, A. M., Tsang, B., Falcon, A. & Stahl, A. Fatty acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissue. Diabetes 55, 3229-3237 (2006). https://doi.org/55/12/3229 [2337/db06-0749

  24. Wu, Q., Ortegon, A. M., Tsang, B., Doege, H., Feingold, K. R. & Stahl, A. FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Mol Cell Biol 26, 3455-3467 (2006). https://doi.org/10.1128/mcb.26.9.3455-3467.2006

  25. Doege, H., Grimm, D., Falcon, A., Tsang, B., Storm, T. A., Xu, H., Ortegon, A. M., Kazantzis, M., Kay, M. A. & Stahl, A. Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia. J Biol Chem 283, 22186-22192 (2008). https://doi.org/M803510200 [pii 10.1074/jbc.M803510200

  26. Doege, H. & Stahl, A. in Encyclopedia of Molecular Pharmacology Vol. 1  (ed Stefan Offermanns and Walter Rosenthal)  494-498 (Springer, 2008).

  27. Falcon, A., Doege, H., Fluitt, A., Tsang, B., Watson, N., Kay, M. A. & Stahl, A. FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase. Am J Physiol Endocrinol Metab 299, E384-393 (2010). https://doi.org/10.1152/ajpendo.00226.2010

  28. Ryu, K. Y., Fujiki, N., Kazantzis, M., Garza, J. C., Bouley, D. M., Stahl, A., Lu, X. Y., Nishino, S. & Kopito, R. R. Loss of polyubiquitin gene Ubb leads to metabolic and sleep abnormalities in mice. Neuropathology and applied neurobiology 36, 285-299 (2010). https://doi.org/10.1111/j.1365-2990.2009.01057.x

  29. Zhou, W., Madrid, P., Fluitt, A., Stahl, A. & Xie, X. S. Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5. J Biomol Screen 15, 488-497 (2010). https://doi.org/10.1177/108705711036970

  30. Kazantzis, M. & Stahl, A. Fatty acid transport proteins, implications in physiology and disease. Biochim Biophys Acta (2011). https://doi.org/10.1016/j.bbalip.2011.09.010

  31. Mishima, T., Miner, J. H., Morizane, M., Stahl, A. & Sadovsky, Y. The expression and function of Fatty Acid transport protein-2 and -4 in the murine placenta. PLoS One 6, e25865 (2011). https://doi.org/10.1371/journal.pone.0025865

  32. Abbasi, A., Thamotharan, M., Shin, B. C., Jordan, M. C., Roos, K. P., Stahl, A. & Devaskar, S. U. Myocardial Macro-Nutrient Transporter Adaptations in the Adult Pre-gestational Female Intra-uterine and Postnatal Growth Restricted Offspring. Am J Physiol Endocrinol Metab (2012). https://doi.org/10.1152/ajpendo.00539.2011

  33. Henkin, A. H., Cohen, A. S., Dubikovskaya, E. A., Park, H. M., Nikitin, G. F., Auzias, M. G., Kazantzis, M., Bertozzi, C. R. & Stahl, A. Real-time noninvasive imaging of fatty acid uptake in vivo. ACS Chem Biol 7, 1884-1891 (2012). https://doi.org/10.1021/cb300194b

  34. Henkin, A. H., Ortegon, A. M., Cho, S., Shen, W. J., Falcon, A., Kraemer, F. B., Lee, S. J. & Stahl, A. Evidence for protein-mediated fatty acid efflux by adipocytes. Acta Physiol (Oxf) 204, 562-570 (2012). https://doi.org/10.1111/j.1748-1716.2011.02367.x

  35. Jeppesen, J., Jordy, A. B., Sjoberg, K. A., Fullekrug, J., Stahl, A., Nybo, L. & Kiens, B. Enhanced Fatty Acid Oxidation and FATP4 Protein Expression after Endurance Exercise Training in Human Skeletal Muscle. PLoS One 7, e29391 (2012). https://doi.org/10.1371/journal.pone.0029391

  36. Nie, B., Park, H. M., Kazantzis, M., Lin, M., Henkin, A., Ng, S., Song, S., Chen, Y., Tran, H., Lai, R., Her, C., Maher, J. J., Forman, B. M. & Stahl, A. Specific bile acids inhibit hepatic fatty acid uptake in mice. Hepatology 56, 1300-1310 (2012). https://doi.org/10.1002/hep.25797

  37. Poreba, M. A., Dong, C. X., Li, S. K., Stahl, A., Miner, J. H. & Brubaker, P. L. Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells. American journal of physiology. Endocrinology and metabolism (2012). https://doi.org/10.1152/ajpendo.00116.2012

  38. Anderson, C. M. & Stahl, A. SLC27 fatty acid transport proteins. Molecular aspects of medicine 34, 516-528 (2013). https://doi.org/10.1016/j.mam.2012.07.010

  39. Godinat, A., Park, H. M., Miller, S. C., Cheng, K., Hanahan, D., Sanman, L. E., Bogyo, M., Yu, A., Nikitin, G. F., Stahl, A. & Dubikovskaya, E. A. A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice. ACS Chem Biol 8, 987-999 (2013). https://doi.org/10.1021/cb3007314

  40. Khalifeh-Soltani, A., McKleroy, W., Sakuma, S., Cheung, Y. Y., Tharp, K., Qiu, Y., Turner, S. M., Chawla, A., Stahl, A. & Atabai, K. Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Nat Med 20, 175-183 (2014). https://doi.org/10.1038/nm.3450

  41. Dubikovskaya, E., Chudnovskiy, R., Karateev, G., Park, H. M. & Stahl, A. Measurement of long-chain fatty acid uptake into adipocytes. Methods in enzymology 538, 107-134 (2014). https://doi.org/10.1016/b978-0-12-800280-3.00007-4

  42. Godinat, A., Budin, G., Morales, A. R., Park, H. M., Sanman, L. E., Bogyo, M., Yu, A., Stahl, A. & Dubikovskaya, E. A. A biocompatible "split luciferin" reaction and its application for non-invasive bioluminescent imaging of protease activity in living animals. Current protocols in chemical biology 6, 169-189 (2014). https://doi.org/10.1002/9780470559277.ch140047

  43. Ye, R., Holland, W. L., Gordillo, R., Wang, M., Wang, Q. A., Shao, M., Morley, T. S., Gupta, R. K., Stahl, A. & Scherer, P. E. Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes beta-cell regeneration. eLife 3 (2014). https://doi.org/10.7554/eLife.03851

  44. Chudnovskiy, R., Thompson, A., Tharp, K., Hellerstein, M., Napoli, J. L. & Stahl, A. Consumption of clarified grapefruit juice ameliorates high-fat diet induced insulin resistance and weight gain in mice. PLoS One 9, e108408 (2014). https://doi.org/10.1371/journal.pone.0108408

  45. Anderson, C. M., Kazantzis, M., Wang, J., Venkatraman, S., Goncalves, R. L., Quinlan, C. L., Ng, R., Jastroch, M., Benjamin, D. I., Nie, B., Herber, C., Van, A. A., Park, M. J., Yun, D., Chan, K., Yu, A., Vuong, P., Febbraio, M., Nomura, D. K., Napoli, J. L., Brand, M. D. & Stahl, A. Dependence of Brown Adipose Tissue Function on CD36-Mediated Coenzyme Q Uptake. Cell reports (2015). https://doi.org/10.1016/j.celrep.2014.12.048

  46. Jha, A. K., Tharp, K. M., Ye, J., Santiago-Ortiz, J. L., Jackson, W. M., Stahl, A., Schaffer, D. V., Yeghiazarians, Y. & Healy, K. E. Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels. Biomaterials 47, 1-12 (2015). https://doi.org/http://dx.doi.org/10.1016/j.biomaterials.2014.12.043

  47. Tharp, K. M. & Stahl, A. Bioengineering Beige Adipose Tissue Therapeutics. Frontiers in endocrinology 6, 164 (2015). https://doi.org/10.3389/fendo.2015.00164

  48. Tharp, K. M., Jha, A. K., Kraiczy, J., Yesian, A., Karateev, G., Sinisi, R., Dubikovskaya, E. A., Healy, K. E. & Stahl, A. Matrix-Assisted Transplantation of Functional Beige Adipose Tissue. Diabetes 64, 3713-3724 (2015). https://doi.org/10.2337/db15-0728

  49. Li, L., Che, L., Tharp, K. M., Park, H. M., Pilo, M. G., Cao, D., Cigliano, A., Latte, G., Xu, Z., Ribback, S., Dombrowski, F., Evert, M., Gores, G. J., Stahl, A., Calvisi, D. F. & Chen, X. Differential Requirement for de novo Lipogenesis in Cholangiocarcinoma and Hepatocellular Carcinoma of Mice and Humans. Hepatology (2016). https://doi.org/10.1002/hep.28508

  50. Jha, A. K., Tharp, K. M., Browne, S., Ye, J., Stahl, A., Yeghiazarians, Y. & Healy, K. E. Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration. Biomaterials 89, 136-147 (2016). https://doi.org/10.1016/j.biomaterials.2016.02.023

  51. Tharp, K. M., Khalifeh-Soltani, A., Park, H. M., Yurek, D. A., Falcon, A., Wong, L., Feng, R., Atabai, K. & Stahl, A. Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis. American Journal of Physiology - Gastrointestinal and Liver Physiology, ajpgi.00316.02015 (2016). https://doi.org/10.1152/ajpgi.00316.2015

  52. Khalifeh-Soltani, A., Ha, A., Podolsky, M. J., McCarthy, D. A., McKleroy, W., Azary, S., Sakuma, S., Tharp, K. M., Wu, N., Yokosaki, Y., Hart, D. O., Stahl, A. & Atabai, K. alpha8beta1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism. eLife 5 (2016). https://doi.org/10.7554/eLife.13063

  53. Johnson, A. R., Qin, Y., Cozzo, A. J., Freemerman, A. J., Huang, M. J., Zhao, L., Sampey, B. P., Milner, J. J., Beck, M. A., Damania, B., Rashid, N., Galanko, J. A., Lee, D. P., Edin, M. L., Zeldin, D. C., Fueger, P. T., Dietz, B., Stahl, A., Wu, Y., Mohlke, K. L. & Makowski, L. Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Molecular metabolism (2016). https://doi.org/10.1016/j.molmet.2016.04.005

  54. Sambeat, A., Gulyaeva, O., Dempersmier, J., Tharp, K. M., Stahl, A., Paul, S. M. & Sul, H. S. LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program. Cell reports 15, 2536-2549 (2016). https://doi.org/10.1016/j.celrep.2016.05.019

  55. Park, H. M., Russo, K. A., Karateev, G., Park, M., Dubikovskaya, E., Kriegsfeld, L. J. & Stahl, A. A System for In Vivo Imaging of Hepatic Free Fatty Acid Uptake. Gastroenterology (2016). https://doi.org/10.1053/j.gastro.2016.10.002

  56. Secco, B., Camire, E., Briere, M. A., Caron, A., Billong, A., Gelinas, Y., Lemay, A. M., Tharp, K. M., Lee, P. L., Gobeil, S., Guimond, J. V., Patey, N., Guertin, D. A., Stahl, A., Haddad, E., Marsolais, D., Bosse, Y., Birsoy, K. & Laplante, M. Amplification of Adipogenic Commitment by VSTM2A. Cell reports 18, 93-106 (2017). https://doi.org/10.1016/j.celrep.2016.12.015

  57. Heffern, M. C., Park, H. M., Au-Yeung, H. Y., Van de Bittner, G. C., Ackerman, C. M., Stahl, A. & Chang, C. J. In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 113, 14219-14224 (2016). https://doi.org/10.1073/pnas.1613628113

  58.  Loskill, P., Sezhian, T., Tharp, K., Lee-Montiel, F. T., Jeeawoody, S., Reese, W. M., Zushin, P.-J. H., Stahl, A. & Healy, K. WAT-on-a-chip: A physiologically relevant microfluidic system incorporating white adipose tissue. Lab on a Chip (2017). https://doi.org/10.1039/C6LC01590E

  59. Riera, C. E., Tsaousidou, E., Halloran, J., Follett, P., Hahn, O., Pereira, M. M. A., Ruud, L. E., Alber, J., Tharp, K., Anderson, C. M., Bronneke, H., Hampel, B., Filho, C. D. M., Stahl, A., Bruning, J. C. & Dillin, A. The Sense of Smell Impacts Metabolic Health and Obesity. Cell Metab 26, 198-211 e195 (2017). https://doi.org/10.1016/j.cmet.2017.06.015

  60. Aron, A. T., Heffern, M. C., Lonergan, Z. R., Vander Wal, M. N., Blank, B. R., Spangler, B., Zhang, Y., Park, H. M., Stahl, A., Renslo, A. R., Skaar, E. P. & Chang, C. J. In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proc Natl Acad Sci U S A 114, 12669-12674 (2017). https://doi.org/10.1073/pnas.1708747114

  61. Tharp, K. M., Kang, M. S., Timblin, G. A., Dempersmier, J., Dempsey, G. E., Zushin, P. H., Benavides, J., Choi, C., Li, C. X., Jha, A. K., Kajimura, S., Healy, K. E., Sul, H. S., Saijo, K., Kumar, S. & Stahl, A. Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues. Cell Metab 27, 602-615 e604 (2018). https://doi.org/10.1016/j.cmet.2018.02.00

  62.  Miranda, D. A., Krause, W. C., Cazenave-Gassiot, A., Suzawa, M., Escusa, H., Foo, J. C., Shihadih, D. S., Stahl, A., Fitch, M., Nyangau, E., Hellerstein, M., Wenk, M. R., Silver, D. L. & Ingraham, H. A. LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity. JCI Insight 3 (2018). https://doi.org/10.1172/jci.insight.96151

  63. West, M. D., Chang, C. F., Larocca, D., Li, J., Jiang, J., Sim, P., Labat, I., Chapman, K. B., Wong, K. E., Nicoll, J., Van Kanegan, M. J., de Grey, A., Nasonkin, I. O., Stahl, A. & Sternberg, H. Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells. Stem cell research & therapy 10, 7 (2019). https://doi.org/10.1186/s13287-018-1087-7

  64. Su, T. A., Shihadih, D. S., Cao, W., Detomasi, T. C., Heffern, M. C., Jia, S., Stahl, A. & Chang, C. J. A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals. J Am Chem Soc 140, 13764-13774 (2018). https://doi.org/10.1021/jacs.8b08014

  65.  Hughes, J. H., Ewy, J. M., Chen, J., Wong, S. Y., Tharp, K. M., Stahl, A. & Kumar, S. Transcriptomic analysis reveals that BMP4 sensitizes glioblastoma tumor-initiating cells to mechanical cues. Matrix Biol (2019). https://doi.org/10.1016/j.matbio.2019.06.002

  66.  Castriota, F., Zushin, P.-J. H., Sanchez, S. S., Phillips, R. V., Hubbard, A., Stahl, A., Smith, M. T., Wang, J.-C. & Merrill, M. A. L. Chronic arsenic exposure impairs adaptive thermogenesis in male C57BL/6J mice. American Journal of Physiology-Endocrinology and Metabolism 318, E667-E677 (2020). https://doi.org/10.1152/ajpendo.00282.2019

  67.  Zhang, Y., Shen, W.-J., Qiu, S., Yang, P., Dempsey, G., Zhao, L., Zhou, Q., Hao, X., Dong, D., Stahl, A., Kraemer, F. B., Leung, L. L. & Morser, J. Chemerin regulates formation and function of brown adipose tissue: Ablation results in increased insulin resistance with high fat challenge and aging. The FASEB Journal 35, e21687 (2021). https://doi.org/https://doi.org/10.1096/fj.202100156R

  68. Timblin, G. A., Tharp, K. M., Ford, B., Winchester, J. M., Wang, J., Zhu, S., Khan, R. I., Louie, S. K., Iavarone, A. T., ten Hoeve, J., Nomura, D. K., Stahl, A. & Saijo, K. Mitohormesis reprogrammes macrophage metabolism to enforce tolerance. Nature Metabolism 3, 618-635 (2021). https://doi.org/10.1038/s42255-021-00392-w

  69. Lei, R., Akins, E. A., Wong, K. C. Y., Repina, N. A., Wolf, K. J., Dempsey, G. E., Schaffer, D. V., Stahl, A. & Kumar, S. Multiwell Combinatorial Hydrogel Array for High-Throughput Analysis of Cell–ECM Interactions. ACS Biomaterials Science & Engineering 7, 2453-2465 (2021). https://doi.org/10.1021/acsbiomaterials.1c00065

  70. Moldavski, O., Zushin, P. H., Berdan, C. A., Van Eijkeren, R. J., Jiang, X., Qian, M., Ory, D. S., Covey, D. F., Nomura, D. K., Stahl, A., Weiss, E. J. & Zoncu, R. 4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor. J Lipid Res 62, 100051 (2021). https://doi.org/10.1016/j.jlr.2021.100051

  71.  Qi, L., Zushin, P.-J. H., Chang, C.-F., Lee, Y. T., Alba, D. L., Koliwad, S. K. & Stahl, A. Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems. Small 18, 2103157 (2022). https://doi.org/https://doi.org/10.1002/smll.202103157

  72. Wang, H., Zhou, Y., Xu, H., Wang, X., Zhang, Y., Shang, R., O'Farrell, M., Roessler, S., Sticht, C., Stahl, A., Evert, M., Calvisi, D. F., Zeng, Y. & Chen, X. Therapeutic efficacy of FASN inhibition in preclinical models of HCC. Hepatology 76, 951-966 (2022). https://doi.org/https://doi.org/10.1002/hep.32359

  73. Huebsch, N., Charrez, B., Neiman, G., Siemons, B., Boggess, S. C., Wall, S., Charwat, V., Jæger, K. H., Cleres, D., Telle, Å., Lee-Montiel, F. T., Jeffreys, N. C., Deveshwar, N., Edwards, A. G., Serrano, J., Snuderl, M., Stahl, A., Tveito, A., Miller, E. W. & Healy, K. E. Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips. Nature Biomedical Engineering 6, 372-388 (2022). https://doi.org/10.1038/s41551-022-00884-4

  74.  Li, V. L., He, Y., Contrepois, K., Liu, H., Kim, J. T., Wiggenhorn, A. L., Tanzo, J. T., Tung, A. S.-H., Lyu, X., Zushin, P.-J. H., Jansen, R. S., Michael, B., Loh, K. Y., Yang, A. C., Carl, C. S., Voldstedlund, C. T., Wei, W., Terrell, S. M., Moeller, B. C., Arthur, R. M., Wallis, G. A., van de Wetering, K., Stahl, A., Kiens, B., Richter, E. A., Banik, S. M., Snyder, M. P., Xu, Y. & Long, J. Z. An exercise-inducible metabolite that suppresses feeding and obesity. Nature (2022). https://doi.org/10.1038/s41586-022-04828-

  75. Bielczyk-Maczynska, E., Zhao, M., Zushin, P.-J. H., Schnurr, T. M., Kim, H.-J., Li, J., Nallagatla, P., Sangwung, P., Park, C. Y., Cornn, C., Stahl, A., Svensson, K. J. & Knowles, J. W. G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis. Nature communications 13, 7408 (2022). https://doi.org/10.1038/s41467-022-35069-9

  76. Chang, C. F., Gunawan, A. L., Liparulo, I., Zushin, P. H., Bertholet, A. M., Kirichok, Y. & Stahl, A. CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression. Antioxidants (Basel) 12 (2022). https://doi.org/10.3390/antiox12010014

  77. Qi, L., Matsuo, K., Pereira, A., Lee, Y. T., Zhong, F., He, Y., Zushin, P. H., Groger, M., Sharma, A., Willenbring, H., Hsiao, E. C. & Stahl, A. Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System. Small, e2203725 (2023). https://doi.org/10.1002/smll.202203725

  78. Chang, C.-F., Gunawan, A. L., Liparulo, I., Zushin, P.-J. H., Vitangcol, K., Timblin, G. A., Saijo, K., Wang, B., Parlakgül, G., Arruda, A. P. & Stahl, A. Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis. The EMBO journal 43, 168-195 (2024). https://doi.org/https://doi.org/10.1038/s44318-023-00008-x

  79. Shihadih, D., Wang, X., Zushin, P. H., Khodakivskyi, P., Park, H. M., Tso, E., Shiblak, J., Misic, A., Louie, S. M., Ward, C., Hellerstein, M., Nomura, D. K., Goun, E., Urigo, F., Calvisi, D. F., Chen, X. & Stahl, A. FATP5 is indispensable for the growth of intrahepatic cholangiocarcinoma. Mol Cancer Res (2024). https://doi.org/10.1158/1541-7786.Mcr-23-0389

  80. Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., Rosnik, A., O’Sullivan, A. M., Davtyan, A., Samudio, B., Thomas, B., Worley, B., Butler, B., Laggner, C., Thayer, D., Moharreri, E., Friedland, G., Truong, H., van den Bedem, H., Ng, H. L., Stafford, K., Sarangapani, K., Giesler, K., Ngo, L., Mysinger, M., Ahmed, M., Anthis, N. J., Henriksen, N., Gniewek, P., Eckert, S., de Oliveira, S., Suterwala, S., PrasadPrasad, S. V. K., Shek, S., Contreras, S., Hare, S., Palazzo, T., O’Brien, T. E., Van Grack, T., Williams, T., Chern, T.-R., Kenyon, V., Lee, A. H., Cann, A. B., Bergman, B., Anderson, B. M., Cox, B. D., Warrington, J. M., Sorenson, J. M., Goldenberg, J. M., Young, M. A., DeHaan, N., Pemberton, R. P., Schroedl, S., Abramyan, T. M., Gupta, T., Mysore, V., Presser, A. G., Ferrando, A. A., Andricopulo, A. D., Ghosh, A., Ayachi, A. G., Mushtaq, A., Shaqra, A. M., Toh, A. K. L., Smrcka, A. V., Ciccia, A., de Oliveira, A. S., Sverzhinsky, A., de Sousa, A. M., Agoulnik, A. I., Kushnir, A., Freiberg, A. N., Statsyuk, A. V., Gingras, A. R., Degterev, A., Tomilov, A., Vrielink, A., Garaeva, A. A., Bryant-Friedrich, A., Caflisch, A., Patel, A. K., Rangarajan, A. V., Matheeussen, A., Battistoni, A., Caporali, A., Chini, A., Ilari, A., Mattevi, A., Foote, A. T., Trabocchi, A., Stahl, A., Herr, A. B., Berti, A., Freywald, A., Reidenbach, A. G., Lam, A., Cuddihy, A. R., White, A., Taglialatela, A., Ojha, A. K., Cathcart, A. M., Motyl, A. A. L., Borowska, A., D’Antuono, A., Hirsch, A. K. H., Porcelli, A. M., Minakova, A., Montanaro, A., Müller, A., Fiorillo, A., Virtanen, A., O’Donoghue, A. J., Del Rio Flores, A., Garmendia, A. E., Pineda-Lucena, A., Panganiban, A. T., Samantha, A., Chatterjee, A. K., Haas, A. L., Paparella, A. S., John, A. L. S., Prince, A., ElSheikh, A., Apfel, A. M., Colomba, A., O’Dea, A., Diallo, B. N. t., Ribeiro, B. M. R. M., Bailey-Elkin, B. A., Edelman, B. L., Liou, B., Perry, B., Chua, B. S. K., Kováts, B., Englinger, B., Balakrishnan, B., Gong, B., Agianian, B., Pressly, B., Salas, B. P. M., Duggan, B. M., Geisbrecht, B. V., Dymock, B. W., Morten, B. C., Hammock, B. D., Mota, B. E. F., Dickinson, B. C., Fraser, C., Lempicki, C., Novina, C. D., Torner, C., Ballatore, C., Bon, C., Chapman, C. J., Partch, C. L., Chaton, C. T., Huang, C., Yang, C.-Y., Kahler, C. M., Karan, C., Keller, C., Dieck, C. L., Huimei, C., Liu, C., Peltier, C., Mantri, C. K., Kemet, C. M., Müller, C. E., Weber, C., Zeina, C. M., Muli, C. S., Morisseau, C., Alkan, C., Reglero, C., Loy, C. A., Wilson, C. M., Myhr, C., Arrigoni, C., Paulino, C., Santiago, C., Luo, D., Tumes, D. J., Keedy, D. A., Lawrence, D. A., Chen, D., Manor, D., Trader, D. J., Hildeman, D. A., Drewry, D. H., Dowling, D. J., Hosfield, D. J., Smith, D. M., Moreira, D., Siderovski, D. P., Shum, D., Krist, D. T., Riches, D. W. H., Ferraris, D. M., Anderson, D. H., Coombe, D. R., Welsbie, D. S., Hu, D., Ortiz, D., Alramadhani, D., Zhang, D., Chaudhuri, D., Slotboom, D. J., Ronning, D. R., Lee, D., Dirksen, D., Shoue, D. A., Zochodne, D. W., Krishnamurthy, D., Duncan, D., Glubb, D. M., Gelardi, E. L. M., Hsiao, E. C., Lynn, E. G., Silva, E. B., Aguilera, E., Lenci, E., Abraham, E. T., Lama, E., Mameli, E., Leung, E., Christensen, E. M., Mason, E. R., Petretto, E., Trakhtenberg, E. F., Rubin, E. J., Strauss, E., Thompson, E. W., Cione, E., Lisabeth, E. M., Fan, E., Kroon, E. G., Jo, E., García-Cuesta, E. M., Glukhov, E., Gavathiotis, E., Yu, F., Xiang, F., Leng, F., Wang, F., Ingoglia, F., van den Akker, F., Borriello, F., Vizeacoumar, F. J., Luh, F., Buckner, F. S., Vizeacoumar, F. S., Bdira, F. B., Svensson, F., Rodriguez, G. M., Bognár, G., Lembo, G., Zhang, G., Dempsey, G., Eitzen, G., Mayer, G., Greene, G. L., Garcia, G. A., Lukacs, G. L., Prikler, G., Parico, G. C. G., Colotti, G., De Keulenaer, G., Cortopassi, G., Roti, G., Girolimetti, G., Fiermonte, G., Gasparre, G., Leuzzi, G., Dahal, G., Michlewski, G., Conn, G. L., Stuchbury, G. D., Bowman, G. R., Popowicz, G. M., Veit, G., de Souza, G. E., Akk, G., Caljon, G., Alvarez, G., Rucinski, G., Lee, G., Cildir, G., Li, H., Breton, H. E., Jafar-Nejad, H., Zhou, H., Moore, H. P., Tilford, H., Yuan, H., Shim, H., Wulff, H., Hoppe, H., Chaytow, H. & The Atomwise, A. P. AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports 14, 7526 (2024). https://doi.org/10.1038/s41598-024-54655-z

  81. Zhao, W., Wang, X., Han, L., Zhang, C., Wang, C., Kong, D., Zhang, M., Xu, T., Li, G., Hu, G., Luo, J., Yee, S. W., Yang, J., Stahl, A., Chen, X. & Zhang, Y. SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis. Nature communications 15, 7522 (2024). https://doi.org/10.1038/s41467-024-51860-2

  82. Qi, L., Groeger, M., Sharma, A., Goswami, I., Chen, E., Zhong, F., Ram, A., Healy, K., Hsiao, E. C., Willenbring, H. & Stahl, A. Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system. Nature communications 15, 7991 (2024). https://doi.org/10.1038/s41467-024-52258-w

  83. Carvalho, E. M., Ding, E. A., Saha, A., Garcia, D. C., Weldy, A., Zushin, P. H., Stahl, A., Aghi, M. K. & Kumar, S. Viscoelastic High-Molecular-Weight Hyaluronic Acid Hydrogels Support Rapid Glioblastoma Cell Invasion with Leader-Follower Dynamics. Advanced materials 36, e2404885 (2024). https://doi.org/10.1002/adma.202404885

  84. Coassolo, L., N, B. D.-S., Nguyen, Q., Wiggenhorn, A., Zhao, M., Wang, D. C., Toomer, D., Lone, J., Wei, Y., Patel, A., Liparulo, I., Kavi, D., Wat, L. W., Reghupaty, S. C., Kim, J. J., Asemi, T., Bielczyk-Maczynska, E., Li, V. L., Moya-Garzon, M. D., Krentz, N. A. J., Stahl, A., Chou, D. H., Luo, L. & Svensson, K. J. Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide. Nature (2025). https://doi.org/10.1038/s41586-025-08683-y

  85.  Gunawan, A. L., Liparulo, I. & Stahl, A. Mammalian mitohormesis: from mitochondrial stressors to organismal benefits. The EMBO journal 44, 5640-5661 (2025). https://doi.org/10.1038/s44318-025-00549-3

  86. Liparulo, I., Bazhin, A., Van Wyhe, G. K., Gunawan, A. L., Dadina, N., Kwon, J. H., Schepartz, A., Goun, E. & Stahl, A. A clickable CoQ imaging probe reveals that cellular uptake and lysosomal trafficking depend on CD36 and NPC1. Redox Biology 89, 103936 (2026). https://doi.org/https://doi.org/10.1016/j.redox.2025.103936

  87. Qi, L., He, Y., Sviercovich, A., Mei, X., Chen, E., Xia, Y., Conboy, M. J., Conboy, I. M. & Stahl, A. Human microphysiological systems of aging recreate the in vivo process expediting evaluation of anti-geronic strategies. Nature Biomedical Engineering (2026). https://doi.org/10.1038/s41551-026-01618-6

  88. Gonzalez-Valero, A., Page, A. C. S., Bertoch, J. M., Alsarhan, F., Kim, J., Alazali, A. A., Srinivas, R. R., Xie, X., Reeves, A. G., Skakuj, K., Coffey, T. G., Virgil, S. C., Nafie, J., He, D., Dao, N., Gunawan, A. L., Dukor, R., Stahl, A., Toste, F. D. & Chang, C. J. Chiral methionine oxidation reagents reveal stereospecific proteome modifications. bioRxiv (2026). https://doi.org/10.64898/2026.03.24.713977

  89. Kim, J., Pham, V. N., Su, T. A., Liparulo, I., Shihadih, D. S., Xiao, T., Xie, X., Aki, Y., Pezacki, A. T., Cao, W., Olzmann, J. A., Rabinowitz, J. D., Stahl, A. & Chang, C. J. A Liver-Targeted Copper Supplement Reduces Metabolic Dysfunction-Associated Liver Steatosis by Increasing Lipolysis and Fatty Acid Oxidation. bioRxiv (2026). https://doi.org/10.64898/2026.05.18.725917

bottom of page