Stem Cell Biology Models
Human stem cell–derived models to investigate critical metabolic regulation and inter-organ communication. Human induced pluripotent stem cells (hiPSCs) provide a powerful platform to overcome these limitations by enabling the generation of patient-relevant models and an isogenic system.
Metabolic diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD) arise from complex interactions between genetic variation, cellular metabolism, endocrine signaling, and communication between metabolically active organs. Understanding these interactions in humans is challenging because traditional in vitro models often fail to capture the genetic diversity, physiological signaling, and multicellular interactions that contribute to disease. Human induced pluripotent stem cells (hiPSCs) provide a powerful platform to overcome these limitations by enabling the generation of patient-relevant and genetically defined cell types, while isogenic stem cell models allow individual genetic or chromosomal factors to be investigated independently of confounding genetic background.
Ongoing Projected include:
1) iPSC XO
2) 148I or 148M PNPLA3 variants